Our Science Programs

aNK PROGRAM

aNK PROGRAM

Cellular senescence is a hallmark of aging and involves the arrest of cell division, which contributes to chronic inflammation, tissue dysfunction, and the progression of various age associated disorders. Activated Natural Killer (aNK) cells are a unique class of immune cells, representing the immune system’s first line of defense, with the innate ability to identify and directly kill abnormal cells by recognizing cellular stress signals. By doing so, aNK cells can effectively regulate immune and inflammatory responses, representing an attractive therapeutic approach. Recognizing this potential, we have developed a novel, patient-specific personalized approach to produce highly activated and ex-vivo expanded, clinical grade aNK cells in a cost-effective, GMP-compliant manner. Importantly, these aNK cells can also be administered without immunosuppressive preconditioning, potentially improving the effectiveness of the therapy.

Our Activated Natural Killer (aNK) cells program is designed to
combat age- related diseases by targeting and reversing cellular senescence.

Learn how our ank program works.

Accelerated telomere shortening is associated with an increased risk of many age-related diseases, including heart disease, diabetes, cancer, and osteoporosis
Senescence and its associated SASP may increase the rate of aging at least in part by the formation of ROS which may induce a chronic inflammatory state in the tissue microenvironment
aNK Cells are part of the immune system and are used to clear senescent cells. aNK cells kill senescent cells by using a protein called perforin and granzyme to damage the senescent cell.
Senescent cells are cleared leaving healthy cells and reducing inflammation.
aNK Publication Highlights

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