Cellular senescence is a hallmark of aging and involves the arrest of cell division, which contributes to chronic inflammation, tissue dysfunction, and the progression of various age associated disorders. Activated Natural Killer (aNK) cells are a unique class of immune cells, representing the immune system’s first line of defense, with the innate ability to identify and directly kill abnormal cells by recognizing cellular stress signals. By doing so, aNK cells can effectively regulate immune and inflammatory responses, representing an attractive therapeutic approach. Recognizing this potential, we have developed a novel, patient-specific personalized approach to produce highly activated and ex-vivo expanded, clinical grade aNK cells in a cost-effective, GMP-compliant manner. Importantly, these aNK cells can also be administered without immunosuppressive preconditioning, potentially improving the effectiveness of the therapy.
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